HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | N1,N1-Dibenzylethane-1,2-diamine | HCID 6394114 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide | HCID 54327882 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a chilled solution of 5.0 g (21 mmol) N,N-dibenzylethylenediamine and 30mL (21 mmol) triethylamine in 20 mL THF is added 1.8 mL (21 mmol) propionylchloride, dropwise. The temperature of the reaction mixture is maintained below 0° C. during addition. The reaction mixture is stirred for 30minutes at 0° C. After this time, the reaction mixture is filtered and the solvents are evaporated to give the product which can be purified via column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051423 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-6c796ddafef5454ba34e40ccd9db3930 |
| Source note | uspto-grants-1991_09 |