Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Chloro-2-methyl-1-propene | HCID 11241 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(p-Hydroxyphenyl)imidazole | HCID 82315 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54173499 | HCID 54173499 | — |
Reaction Steps
Suspend 40 g (0.25 mol) of 4-(1H-imidazol-1-yl)phenol in 280 mL of THF and treat with 15 9 (0.375 mol) of a 60% dispersion of sodium hydride in mineral oil. Stir this suspension for 20 min and then add 27.1 mL (0.25 mol) of 3-chloro-2-methylpropene. Heat this mixture to 100° C. for 3 h. After this time, add 250 mL of water and 250 mL of diethyl ether and separate the layers. Re-extract the aqueous layer with 2×250 mL of diethyl ether. Evaporate the combined ether extracts on a rotary evaporator. Triturate with 300 mL of hexanes and filter off the resulting solid to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05051423 |
|---|
| Source dataset | uspto-grants-1991_09 |
|---|
| ORD ID | ord-425298c8cec744898583c02fb2364a38 |
|---|
| Source note | uspto-grants-1991_09 |
|---|
