Sulfuric Acid → HCID 54536771, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 27 g (0.126 mol) of 1-[4-(2-methyl-2-propenyloxy)phenyl]-1H-imidazole in a solution of 78 mL of glacial acetic acid and 29 mL of acetonitrile. Cool this solution to 0° C. over an ice bath and add 29.0 mL of 95% sulfuric acid dropwise at a rate to keep temperature below 15° C. Upon completionof the addition, stir overnight at room temperature. After this time, make basic (pH=12-14) with 4 N sodium hydroxide. Dilute with 400 mL of water and extract with 3×400 mL of diethyl ether. Concentrate the combinedether extracts to 350 mL on the rotary evaporator and cool in the refrigerator for 1 h. Filter off the resulting precipitate to provide the title compound.

Provenance & Evidence