Phosphoric Acid → HCID 67689868, compound

HRID 728831Notes

Reaction equation

HRID 728831 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:19]=[CH:18][C:9]([C:10]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:11])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[O:20]1[CH:22]([CH2:23][O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:21]1.[OH:31][P:32]([OH:35])([OH:34])=[O:33]>CO.C(O)C>[P:32](=[O:31])([OH:35])([OH:34])[OH:33].[OH:20][CH:22]([CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:21][N:15]1[CH2:16][CH2:17][N:12]([C:10](=[O:11])[C:9]2[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:19][CH:18]=2)[CH2:13][CH2:14]1

Participants

6

Reactant 3

HCID 1004Phosphoric AcidHCID 31217Phenyl glycidyl etherHCID 147398841-[4-[(Methylsulfonyl)amino]benzoyl]piperazine

Product 1

HCID 67689868HCID 67689868, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To a solution of 13.31 g (47 mmol) 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine in 50 mL methanol add 6.4 mL (47 mmol) 1,2-epoxy-3-phenoxypropane. Stir the reaction mixture at roomtemperature under a nitrogen atmosphere. Follow the progress of the reaction by thin-layer chromatography on silica gel (methylene chloride: MeOH, 9:1). When the reaction is complete, remove the solvents in vacuo toobtain an oil. Dissolve the oil in ethanol with one equivalent of H3PO4 and remove the solvents to obtain the title compound.

Workup

  1. customthe progress of the reaction by thin-layer chromatography on silica gel (methylene chloride: MeOH, 9:1)
  2. customremove the solvents in vacuo toobtain an oil
  3. customremove the solvents

Sources & evidence

ORD record
ord-396e9875a9ef47dbb1e2422dc3db1ff7
Source dataset
uspto-grants-1991_09
Patent number
US05051423

Reaction notes

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