HCID 86745092, compound → HCID 67919276, compound

Participants

Reaction Steps

0.44 g of E-2-formylamino-4-benzyl-5-diethylphosphono-3-pentenoic acid ethyl ester are dissolved in 8 ml of 4.5N hydrochloric acid and heated at 85° for 48 hours. After concentration in vacuo, the residue is dissolved in a small amount of ethanol and 1 ml of ethanol/propylene oxide(1:1) is added dropwise thereto. The resulting white precipitate is filtered off and, after recrystallisation from water, E-2-amino-4-benzyl-5-phosphono-3-pentenoic acid is obtained in the form ofcolourless needles, m.p. 196°-198°.

Provenance & Evidence