Triethyl phosphite → HCID 86745095, compound

Participants

Reaction Steps

3.7 g of E-2-formylamino-4-bromomethyl-3,6-heptadienoic acid methyl ester are dissolved in 37 ml of triethyl phosphite, and the mixture is heated at75° for 8 hours. Excess triethyl phosphite is then distilled off under a high vacuum. Purification by column chromatography (silica gel, methanol/ethyl acetate 1:10) yields E-2-formylamino-4-diethylphosphonomethyl-3,6-heptadienoic acid methyl ester in the form of a colourless oil, 1H-NMR (CDCl3): 2.54 (d,2H, P--CH2); 3.10 (m, 2H, C(5)--H); 5.10 (m, 2H, C(7)--H); 5.37 (d, 1 H, C(2)--H); 5.74 (m, 1 H, C(6)--H).

Provenance & Evidence