1-Ethyl (3E)-2-amino-4-methyl-5-phosphono-3-pentenoate → CGP 37849

HRID 728894Notes

Reaction equation

HRID 728894 reaction equation
C([O:3][C:4](=[O:15])[CH:5]([NH2:14])/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])C>O>[NH2:14][CH:5](/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])[C:4]([OH:15])=[O:3]

Participants

3

Reactant 1

HCID 63723341-Ethyl (3E)-2-amino-4-methyl-5-phosphono-3-pentenoate

Product 1

HCID 5950212CGP 37849

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12 g of E-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester are stirred under reflux in 70 ml of water for 19 hours. The reaction mixture is slowly cooled to room temperature, stirred in an ice bath for one hour,filtered and washed with cold water. In this manner there is obtained E-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the form of the monohydrate, m.p. 163° (decomp.).

Workup

  1. filtrationfiltered
  2. washwashed with cold water

Sources & evidence

ORD record
ord-7ad34d81d4664fed9c5bb1a95169289a
Source dataset
uspto-grants-1991_09
Patent number
US05051413

Reaction notes

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