HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 728909Generated: October 26, 2026
Triethylamine → 1-Benzyl-4-phenyl-piperazine-2-carboxamide
https://huagongshe.com/reaction/728909
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Dibromopropionamide | HCID 85798 | — |
| Reactant | N-benzyl-N'-phenylethane-1,2-diamine | HCID 5302982 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Benzyl-4-phenyl-piperazine-2-carboxamide | HCID 10990097 | — |
Reaction Steps
To dimethylformamide (300 mL) add N-phenyl-N'-phenylmethyl-1,2-ethanediamine (83 g, 0.37 mol), 2,3-dibromopropanamide (90 g, 0.39 mol) and triethylamine (41 g, 0.40 mol). Heat the resulting mixture at 110° C. and follow the progressof the reaction by thin-layer chromatography. Upon completion of the reaction add 1N NaOH until basic and add ethyl ether. Filter the precipitate that forms and recrystallize from 2-propanol to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05051422 |
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| Source dataset | uspto-grants-1991_09 |
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| ORD ID | ord-2563d0894aa240b59a86ea0471d3b78a |
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| Source note | uspto-grants-1991_09 |
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