2,3-Dibromopropionamide → 4-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 728921Notes

Reaction equation

HRID 728921 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Br[CH:21]([CH2:25]Br)[C:22]([NH2:24])=[O:23]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:21]([C:22]([NH2:24])=[O:23])[CH2:25]1

Participants

3

Reactant 2

HCID 857982,3-DibromopropionamideHCID 14998755N-(2-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Product 1

HCID 149987564-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-(2-methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine (15.4 g, 60.2 mmol) with 2,3-dibromopropanamide (27.7 g, 0.12 mol) to give the title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-39f5f5ecb7e94d20b100cf45cd25a5cb
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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