HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[3-(Acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide | HCID 14998758 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide | HCID 14998814 | — |
Reaction Steps
To 4-[3-(acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide (14.0g, 39.9 mmol) in methanol (115 mL) add 6N aqueous hydrochloric acid (28 mL). Stir the reaction at reflux. Monitor the progress of the reaction by thin-layer chromatography. Upon completion of the reaction adjust the pH to 12 with 4N aqueous NaOH to obtain a white precipitate. Filter the precipitate to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051422 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-4b4d60452fe446f8977735caac5606e0 |
| Source note | uspto-grants-1991_09 |