4-[(Methylsulfonyl)amino]benzoyl chloride → N-[[4-(3-Aminophenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide

HRID 728931Notes

Reaction equation

HRID 728931 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:10]([CH2:21][NH2:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:23][S:24]([NH:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1)(=[O:26])=[O:25]>>[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:10]([CH2:21][NH:22][C:32](=[O:33])[C:31]3[CH:35]=[CH:36][C:28]([NH:27][S:24]([CH3:23])(=[O:26])=[O:25])=[CH:29][CH:30]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987894-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinemethanamine

Product 1

HCID 14998790N-[[4-(3-Aminophenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide

Procedure

In a manner similar to Preparation 3, react 4-(3-aminophenyl)-1-(phenylmethyl)-2-piperazinemethanamine (4.8 g, 16 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (3.8 g, 16 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-7943fd6edbc148f383e33388984c6224
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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