2,3-Dibromopropionamide → 4-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide

HRID 728934Notes

Reaction equation

HRID 728934 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.Br[CH:24]([CH2:28]Br)[C:25]([NH2:27])=[O:26]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:9][CH2:10][N:11]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)[CH:24]([C:25]([NH2:27])=[O:26])[CH2:28]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 857982,3-DibromopropionamideHCID 14998759HCID 14998759, compound

Product 1

HCID 149987604-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-(3-chlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine (13.3 g, 41 mmol) with 2,3-dibromopropanamide (19.1 g, 166 mmol) to obtainthe title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-cf1fe96969da403d99132a67e915f2b3
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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