4-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide → 4-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanamine

HRID 728935Notes

Reaction equation

HRID 728935 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([C:25]([NH2:27])=O)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH2:27])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 149987604-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 149987734-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanamine

Procedure

In a manner similar to Preparation 2, react 4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide(6.0 g, 15 mmol) with lithium aluminum hydride (1.2 g, 31 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-30647a4259cc4e7598fc85b29853689f
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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