4-[(Methylsulfonyl)amino]benzoyl chloride → N-[[4-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide

HRID 728936Notes

Reaction equation

HRID 728936 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH2:26])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][S:28]([NH:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1)(=[O:30])=[O:29]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH:26][C:36](=[O:37])[C:35]3[CH:39]=[CH:40][C:32]([NH:31][S:28]([CH3:27])(=[O:30])=[O:29])=[CH:33][CH:34]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987734-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanamine

Product 1

HCID 14998791N-[[4-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide

Procedure

In a manner similar to Preparation 3, react 4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanamine(3.0 g, 7.9 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (2.4 g, 10mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-7db5782d9f67430894ca52fb229ae72b
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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