HRID728936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11791119

4-[(Methylsulfonyl)amino]benzoyl chloride

C8H8ClNO3S

结构：COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2CN)cc1OC

HCID14998773

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2CNC(=O)c2ccc(NS(C)(=O)=O)cc2)cc1OC

HCID14998791

未命名化合物

PROCEDURE

实验过程

In a manner similar to Preparation 3, react 4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanamine(3.0 g, 7.9 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (2.4 g, 10mmol) to obtain the title compound.

WORKUP

后处理

customIn a manner similar to Preparation 3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7db5782d9f67430894ca52fb229ae72b
来源数据集: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05051422
来源说明: uspto-grants-1991_09

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH2:26])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][S:28]([NH:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1)(=[O:30])=[O:29]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH:26][C:36](=[O:37])[C:35]3[CH:39]=[CH:40][C:32]([NH:31][S:28]([CH3:27])(=[O:30])=[O:29])=[CH:33][CH:34]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1