N-(3,5-Dichlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide → N-(3,5-Dichlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

HRID 728944Notes

Reaction equation

HRID 728944 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=O)[CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

3

Reactant 2

HCID 14998823N-(3,5-Dichlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 14998761N-(3,5-Dichlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

Procedure

In a manner similar to Preparation 2, react N-(3,5-dichlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide with lithium aluminum hydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-57bc02f7ccf141998fd42352cabd578d
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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