2,3-Dibromopropionamide → 4-(3,5-Dichlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide

HRID 728945Notes

Reaction equation

HRID 728945 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.Br[CH:25]([CH2:29]Br)[C:26]([NH2:28])=[O:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:10][CH2:11][N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=3)[CH:25]([C:26]([NH2:28])=[O:27])[CH2:29]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

3

Reactant 2

HCID 857982,3-DibromopropionamideHCID 14998761N-(3,5-Dichlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

Product 1

HCID 149987624-(3,5-Dichlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-(3,5-dichlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine with 2,3-dibromopropanamide to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-ee66ead8291d49aa90c70d00073b1958
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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