2,3-Dibromopropionamide → 4-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 728948Notes

Reaction equation

HRID 728948 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][CH2:12][CH2:13][NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Br[CH:23]([CH2:27]Br)[C:24]([NH2:26])=[O:25]>>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([N:11]2[CH2:12][CH2:13][N:14]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:23]([C:24]([NH2:26])=[O:25])[CH2:27]2)[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Participants

3

Reactant 2

HCID 857982,3-DibromopropionamideHCID 19755034N-(3,5-dimethoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Product 1

HCID 149987644-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-(3,5-dimethoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine with 2,3-dibromopropanamide to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-5130846e541e4ddcb81319b15ef053e1
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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