4-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide → 4-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

HRID 728949Notes

Reaction equation

HRID 728949 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]([C:24]([NH2:26])=O)[CH2:12]2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]([CH2:24][NH2:26])[CH2:12]2)[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Participants

3

Reactant 2

HCID 149987644-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 149987744-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

Procedure

In a manner similar to Preparation 2, react 4-(3,5-dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide with lithium aluminum hydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-ad8cf8401d4247fc9810307ba1342eb9
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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