HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → 4-(1H-Imidazol-1-yl)benzenesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | 1-Phenylimidazole | HCID 81595 | — |
| Product | 4-(1H-Imidazol-1-yl)benzenesulfonyl chloride | HCID 14998830 | — |
Reaction Steps
To chlorosulfonic acid cooled to 0° C. in an ice bath is added portionwise 1-phenyl-1H-imidazole. Monitor the progress of the reaction bythin-layer chromatography. When the reaction is complete, quench the mixture on ice. Saturated aqueous NaHCO3 is added until the solution is no longer acidic. Extract the mixture with CH2Cl2. Dry the organic layer over anhydrous Na2SO4 and remove the solvent in vacuo to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051422 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-6cc879f52e8e41ef9074507710849770 |
| Source note | uspto-grants-1991_09 |