2,3-dibromo-N-(2-methoxyethyl)-N-(4-nitrophenyl)propanamide → 4-(4-Ethoxyphenyl)-N-(2-methoxyethyl)-N-(4-nitrophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 728965Notes

Reaction equation

HRID 728965 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:6][CH:5]=1)[CH3:2].Br[CH:22]([CH2:39]Br)[C:23]([N:25]([CH2:35][CH2:36][O:37][CH3:38])[C:26]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[CH:28][CH:27]=1)=[O:24]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][N:13]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:22]([C:23]([N:25]([CH2:35][CH2:36][O:37][CH3:38])[C:26]3[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[CH:28][CH:27]=3)=[O:24])[CH2:39]2)=[CH:6][CH:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 149988362,3-dibromo-N-(2-methoxyethyl)-N-(4-nitrophenyl)propanamideHCID 14998837N-(4-Ethoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Product 1

HCID 149988384-(4-Ethoxyphenyl)-N-(2-methoxyethyl)-N-(4-nitrophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 23, react N-(4-ethoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine with 2,3-dibromo-N-(2-methoxyethyl)-N-(4-nitrophenyl)propanamide to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 23

Sources & evidence

ORD record
ord-46e4615de6c848de992788efced35430
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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