HRID728970

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11791119

4-[(Methylsulfonyl)amino]benzoyl chloride

C8H8ClNO3S

结构：COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2CNC(C)C)cc1OC

HCID14998781

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2CN(C(=O)c2ccc(NS(C)(=O)=O)cc2)C(C)C)cc1OC

HCID19755015

未命名化合物

PROCEDURE

实验过程

In a manner similar to Preparation 3, react 4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-N-(1-methylethyl)-2-piperazinemethanamine with 4-[(methylsulfonyl)amino]benzoyl chloride to obtainthe title compound.

WORKUP

后处理

customIn a manner similar to Preparation 3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dfcf9ca4d3b04a25b133c7c88edc1d3e
来源数据集: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05051422
来源说明: uspto-grants-1991_09

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH:26][CH:27]([CH3:29])[CH3:28])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:30][S:31]([NH:34][C:35]1[CH:43]=[CH:42][C:38]([C:39](Cl)=[O:40])=[CH:37][CH:36]=1)(=[O:33])=[O:32]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][N:26]([CH:27]([CH3:29])[CH3:28])[C:39](=[O:40])[C:38]3[CH:42]=[CH:43][C:35]([NH:34][S:31]([CH3:30])(=[O:33])=[O:32])=[CH:36][CH:37]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1