4-[(Methylsulfonyl)amino]benzoyl chloride → HCID 19755015, compound

HRID 728970Notes

Reaction equation

HRID 728970 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][NH:26][CH:27]([CH3:29])[CH3:28])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:30][S:31]([NH:34][C:35]1[CH:43]=[CH:42][C:38]([C:39](Cl)=[O:40])=[CH:37][CH:36]=1)(=[O:33])=[O:32]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:10]([CH2:25][N:26]([CH:27]([CH3:29])[CH3:28])[C:39](=[O:40])[C:38]3[CH:42]=[CH:43][C:35]([NH:34][S:31]([CH3:30])(=[O:33])=[O:32])=[CH:36][CH:37]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987814-(3-Chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-N-(1-methylethyl)-2-piperazinemethanamine

Product 1

HCID 19755015HCID 19755015, compound

Procedure

In a manner similar to Preparation 3, react 4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-N-(1-methylethyl)-2-piperazinemethanamine with 4-[(methylsulfonyl)amino]benzoyl chloride to obtainthe title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-dfcf9ca4d3b04a25b133c7c88edc1d3e
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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