HCID 19755038, compound → HCID 131717009, compound

HRID 728983Notes

Reaction equation

HRID 728983 reaction equation
[ClH:1].[N:2]1([C:7]2[CH:8]=[C:9]([N:13]3[CH2:18][CH2:17][N:16](CC4C=CC=CC=4)[CH:15]([CH2:26][NH:27][C:28](=[O:40])[C:29]4[CH:34]=[CH:33][C:32]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])=[CH:31][CH:30]=4)[CH2:14]3)[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][N:4]=[CH:3]1>[Pd]>[ClH:1].[N:2]1([C:7]2[CH:8]=[C:9]([N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:26][NH:27][C:28](=[O:40])[C:29]4[CH:34]=[CH:33][C:32]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])=[CH:31][CH:30]=4)[CH2:14]3)[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

3

Reactant 1

HCID 19755038HCID 19755038, compound

Product 1

HCID 131717009HCID 131717009, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a manner similar to Example 1, react N-[[4-[3-(1H-imidazol-1-yl)phenyl-]-1-(phenylmethyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride (2.5 g, 4.4 mmol) with H2 over Pd on carbon (1.2 g) to obtain the title compound.

Sources & evidence

ORD record
ord-8255815038cf4f58894f3c36014dbfa4
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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