2-(4-Hydroxyphenyl)benzothiazole → HCID 6483422, compound

HRID 728995Notes

Reaction equation

HRID 728995 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.Br[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]1[O:27][N:26]=[C:25]([CH3:28])[CH:24]=1>>[CH3:28][C:25]1[CH:24]=[C:23]([CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[S:9][C:10]4[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=4[N:12]=3)=[CH:6][CH:7]=2)[O:27][N:26]=1

Participants

3

Reactant 2

HCID 957452-(4-Hydroxyphenyl)benzothiazoleHCID 135440465-(5-Bromopentyl)-3-methylisoxazole

Product 1

HCID 6483422HCID 6483422, compound

Procedure

2-{4-[[5-(3-Methyl-5-isoxazolyl)pentyl]oxy]phenyl}benzothiazole [II; R1 and R2 =H, Het=benzothiazol-2-yl] was prepared from 5 g 2-(4-hydroxyphenyl)benzothiazole and 5.1 g 5-(5-bromopentyl)-3-methylisoxazole according to the procedure of Example 1: yield 6.9 g, m.p. 120°-121° C. when recrystallized from triethylamine and then from isopropyl acetate.

Workup

  1. customyield 6.9 g, m.p. 120°-121° C. when recrystallized from triethylamine

Sources & evidence

ORD record
ord-e332a1f689e14fab994b9d85fbfdd8c0
Source dataset
uspto-grants-1991_09
Patent number
US05051437

Reaction notes

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