Hydrochloric Acid → HCID 14989449, compound

Participants

Reaction Steps

The compound of Example 2 (0.11 g, 0.199 mmol) was mixed with 3.0 ml of 4:1methanol/THF and 0.3 ml of 1M LiOH and allowed to react at 0° C. for15 minutes then at room temperature for 2.5 hours. The reaction mixture waspoured into ethyl acetate and 0.5N hydrochloric acid, and the ethyl acetatelayer was washed with brine, dried over sodium sulfate, and concentrated togive the product.

Provenance & Evidence