Sodium Cyanide → HCID 14995020, compound

HRID 729040Notes

Reaction equation

HRID 729040 reaction equation
S(O[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=3)=[CH:16][CH:15]=2)[CH:8]=1)(=O)(=O)C.[C-:32]#[N:33].[Na+]>CS(C)=O>[N:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:30]=[CH:31][C:22]=1[CH2:21][O:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][C:9]2[CH:8]=[C:7]([CH2:6][C:32]#[N:33])[CH:12]=[CH:11][CH:10]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 14995019HCID 14995019, compound

Product 1

HCID 14995020HCID 14995020, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

3-(4-(2-Quinolinylmethyloxy)benzyl)benzyl alcohol mesylate (0.0018 mol) with sodium cyanide (0.0036 mol) in dimethylsulfoxide (10 ml) is stirred at ambient temperature. After the consumption of sulfate, the reaction is diluted with water and extracted with ethyl acetate. The organic extracts are dried and evaporated to give 3-(4-(2-quinolinylmethyloxy)benzyl)phenylacetonitrile.

Workup

  1. customAfter the consumption of sulfate
  2. additionthe reaction is diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe organic extracts are dried
  5. customevaporated

Sources & evidence

ORD record
ord-a39d1c7821fd44ba82b15e418a7d7bc8
Source dataset
uspto-grants-1991_09
Patent number
US05051427

Reaction notes

Loading…