Dimethylformamide dimethyl acetal → N4-Dimethylaminomethylene-2',3'-dideoxy-3'-fluorocytidine

Participants

Reaction Steps

Previously dried 2',3'-dideoxy-3'-fluorocytidine (300 mg, 1.3 mmoles) was treated with dimethylformamide dimethylacetal (0.45 g, 3.8 mmoles) in anhydrous DMF (5 mL) under a nitrogen atmosphere. The contents were stirred overnight and the solvents removed by rotary evaporation. The syrupy residue remaining was crystallized from ethanol to give white crystals (276 mg, 75%) of the product N4 -dimethylaminomethylene-2',3'-dideoxy-3'-fluorocytidine which were shown to have the following properties:

Provenance & Evidence