Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 729057Generated: October 27, 2026

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → Ciprofloxacin

https://huagongshe.com/reaction/729057

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 5210422—
Reactant4-(t-Butyldimethylsilyl)-1-methyl piperazineHCID 19434781—
ProductCiprofloxacinHCID 2764—

Reaction Steps

In a manner similar to that of Example 1, 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (II, R1 : cyclopropyl; X: fluoro) is reacted with 1-butylmethylsilyl piperazine (III, R2 : hydrogen; R3 and R4 : methyl; R5: t-butyl) to give a solid compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05051505
Source datasetuspto-grants-1991_09
ORD IDord-3b2b24a815f34b79950df28b2adb7225
Source noteuspto-grants-1991_09