Sodium Bicarbonate → 6-Chloropyridine-3-carbaldehyde

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Reaction Steps

A mixture of 7.0 g (0.0356 mol) of 2-chloro-5-dichloromethyl-pyridine and 100 ml of water is heated to reflux. The pH is kept between 4 and 7 by adding a saturated sodium hydrogencarbonate solution dropwise. After 2 hours, the mixture is cooled, extracted using ethyl acetate and the solvent is carefully removed from the organic phase by distillation in a water jet vacuum. 4.6 g (95% of theory) of 6-chloro-nicotinaldehyde of melting point 70° C. are obtained.

Provenance & Evidence