HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Toluidine → HCID 44366622, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | 4-Chloro-3-(2-chloroethyl)-2-methylquinoline | HCID 820320 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 44366622 | HCID 44366622 | 43.5% |
Reaction Steps
2-Methyl-3-(2-chloroethyl)-4-chloroquinoline (45 g, 0.16 mol), 2-methylaniline (35 ml, 0.32 mol) and ethanol (300 ml) were heated to 150° C. in a pressure vessel for 17 hours, then concentrated in vacuo. The product crystallised as the hydrochloride salt. Conversion to free base and recrystallisation from ethyl acetate yielded 1-(2-methylphenyl)-4-methyl-2,3-dihydropyrrolo[3,2-c]quinoline (19.1 g, 43%), m.p. 148°-150°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051508 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-22c83cafbf924138ae7553a64ae12124 |
| Source note | uspto-grants-1991_09 |