Sodium Methoxide → 1-(2-Methylphenyl)-4-methoxy-6-methyl-2,3-dihydropyrrolo-[3,2-c]quinoline

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Reaction Steps

1-(2-Methylphenyl)-4-chloro-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline (0.62 g, 2 mmol), sodium methoxide (1.0 g, 18.5 mmol) and methanol (30 ml)were heated to 170° C. in a pressure vessel for 18 hours, then the solvent evaporated in vacuo. Conversion to free base, chromatography (silica gel. 40:60 dichloromethane/petroleum ether) and recrystallisation from methanol yielded 1-(2-methylphenyl)-4-methoxy-6-methyl-2,3-dihydropyrrolo- [3,2-c]quinoline(0.30 g), m.p. 107°-108°.

Provenance & Evidence