Ammonia → HCID 19090926, compound

HRID 729143Notes

Reaction equation

HRID 729143 reaction equation
[C:1]([CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8])#[N:2].N>[Ni].C(O)C>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 19090879HCID 19090879, compound

Product 1

HCID 19090926HCID 19090926, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4,35 g of ethyl 2-cyanoethyl(di-n-propyloxymethyl)phosphinate,10 g of ammonia and 2.3 g of Raney-Nickel :n 170 ml of ethanol is hydrogenated for 10.5 hours. The catalyst is filtered off and the solvent is removed by evaporation. The crude oil is purified by distillation to yield ethyl 3-aminopropyl(di-n-propyloxymethyl)phosphinate as a colourlessoil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed by evaporation
  3. distillationThe crude oil is purified by distillation

Sources & evidence

ORD record
ord-62a7450ffbc343f3bd10e23a4fc407a6
Source dataset
uspto-grants-1991_09
Patent number
US05051524

Reaction notes

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