Ethanol → HCID 53872425, compound

HRID 729146Notes

Reaction equation

HRID 729146 reaction equation
C(OC([P:8]([CH:13]1[CH2:17][CH2:16][CH2:15][O:14]1)(=[O:12])[O:9][CH2:10][CH3:11])OCC)C.C(O)C.C[Si](Cl)(C)C>ClCCl>[CH2:10]([O:9][P:8]([CH:13]1[CH2:17][CH2:16][CH2:15][O:14]1)[OH:12])[CH3:11]

Participants

5

Reactant 3

HCID 702EthanolHCID 6397ChlorotrimethylsilaneHCID 10355539HCID 10355539, compound

Product 1

HCID 53872425HCID 53872425, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1 g of ethyl 1,1-diethoxymethyl(tetrahydrofuran-2-yl)phosphinate in 10 ml of dichloromethane containing 1% (b.v.) of ethanol is treated with 0.71 g of trimethylsilylchloride. The faintly cloudy solution is stirred overnight at room temperature after which time thin layer chromatography indicates complete reaction. Removal of the solvent in vacuo affords a colourless oil which after distillation yields P-tetrahydrofuran-2-yl-phosphonous acid ethyl ester, b.p. 90°/8 ×10-2 mbar.

Workup

  1. customreaction
  2. customRemoval of the solvent in vacuo
  3. customaffords a colourless oil which
  4. distillationafter distillation

Sources & evidence

ORD record
ord-c4aed8f2d49f48f29f70837a26879435
Source dataset
uspto-grants-1991_09
Patent number
US05051524

Reaction notes

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