2-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide → HCID 178448691, compound

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Reaction Steps

A solution of 2-butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide (0.110 g, 0.33 mmol) and 3-amino-1,2,4-triazole (0.083 g, 0.991 mmol) in DMF (0.5 mL) was heated at 140° C. for 25 mins in a microwave reactor. The residue was purified by preparative HPLC (Column Ace C8 (5u), 0.1M NH4OAc/MeCN, gradient) to give the title compound (0.0036 g, 2.2%); 1H-NMR (500 MHz, CD3CN): δ 7.78 (s, 1H), 7.20-7.40 (m, 5H), 3.74 (t, 2H), 1.84-1.76 (m, 2H), 1.51-1.42 (m, 2H), 0.99 (t, 3H); Mass Spectrum: M+H 348.

Provenance & Evidence