6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline → HCID 11605944, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide (1.000 g, 3.336 mmol), tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.828 g, 3.336 mmol) and TEA (0.460 ml, 3.33 gmmol) in dry MeCN (5 ml) was heated in a microwave reactor at 120° C. for 35 mins, 140° C. for 20 mins and 160° C. for 45 mins.

Provenance & Evidence