4-(Trifluoromethoxy)aniline → HCID 11626338, compound

Participants

Reaction Conditions

Reaction Steps

2-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide (110 mg, 0.330 mmol) was dissolved in dry DMF (0.5 mL) under nitrogen atmosphere. [4-(Trifluoromethoxy)phenyl]amine (175 mg, 0.991 mmol) was added and the reaction mixture was heated in a microwave reactor for 25 mins at 140° C. The crude product was purified by preparative HPLC affording the title compound (84 mg, 56.6%). 1H NMR (500 MHz, CD3CN): δ 1.00 (t, 3H), 1.43-1.52 (m, 2H), 1.78-1.85 (m, 2H), 3.75 (t, 2H), 6.85-6.93 (m, 4H), 7.11-7.20 (m, 4H), 7.24-7.29 (m, 1H), 7.82 (bs, 1H).

Provenance & Evidence