3-morpholin-4-yl-1H-1,2,4-triazol-5-amine → HCID 11604480, compound

HRID 729317Notes

Reaction equation

HRID 729317 reaction equation
Cl[C:2]1[C:3](=[O:19])[N:4]([CH2:15][CH2:16][O:17][CH3:18])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N:20]1([C:26]2[N:30]=[C:29]([NH2:31])[NH:28][N:27]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:18][O:17][CH2:16][CH2:15][N:4]1[C:3](=[O:19])[C:2]([NH:31][C:29]2[NH:28][N:27]=[C:26]([N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[N:30]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 44173793-morpholin-4-yl-1H-1,2,4-triazol-5-amineHCID 672439094-Chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11604480HCID 11604480, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 3-morpholin-4-yl-1H-1,2,4-triazol-5-amine in a similar manner as described for Example 13. 1H NMR (400 MHz, CD3CN): δ 7.49-7.61 (m, 5H), 5.71 (bs, 2H), 3.94 (t, 2H), 3.71 (t, 2H), 3.58-3.62 (m, 4H), 3.37 (s, 3H), 3.10-3.14 (m, 4H); Mass Spectrum: M+H+

Sources & evidence

ORD record
ord-67e65fe39ae14f4fa43831e192b7fa6c
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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