4-(Difluoromethoxy)aniline → 2-[(6-Aminopyridin-3-yl)methyl]-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Participants

Reaction Steps

The title compound was prepared from tert-butyl (5-{[4-{[4-(difluoromethoxy)phenyl]amino}-1,1-dioxido-3-oxo-5-phenylisothiazol-2(3H)-yl]methyl}pyridin-2-yl)carbamate and 4-(difluoromethoxy)aniline in a similar manner as described for e.g. Example 5. 1H NMR (400 MHz, DMSO): δ 3.57-3.71 (m, 2H), 5.77 (s, 2H), 6.15 (d, 1H), 6.91 (d, 1H), 7.23-7.28 (m, 2H), 7.38-7.48 (m, 6H), 7.86 (d, 1H); Mass Spectrum: M+H+ 473.

Provenance & Evidence