Benzenamine, 2,5-diethoxy-4-(4-morpholinyl)- → HCID 11533837, compound

HRID 729325Notes

Reaction equation

HRID 729325 reaction equation
[CH2:1]([N:5]1[C:9](=[O:10])[C:8](Cl)=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:6]1(=[O:19])=[O:18])[CH2:2][CH2:3][CH3:4].[CH2:20]([O:22][C:23]1[CH:29]=[C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[C:27]([O:36][CH2:37][CH3:38])=[CH:26][C:24]=1[NH2:25])[CH3:21]>>[CH2:1]([N:5]1[C:9](=[O:10])[C:8]([NH:25][C:24]2[CH:26]=[C:27]([O:36][CH2:37][CH3:38])[C:28]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[CH:29][C:23]=2[O:22][CH2:20][CH3:21])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:6]1(=[O:19])=[O:18])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 98599Benzenamine, 2,5-diethoxy-4-(4-morpholinyl)-HCID 672426232-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11533837HCID 11533837, compound

Procedure

The title compound was prepared from 2-butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 2,5-diethoxy-4-morpholin-4-ylaniline in a similar manner as described for e.g. Examples 6-9, 22-25, 28 and 32-35. 1H NMR (400 MHz, CD3CN): δ 7.46 (bs, 1H), 7.27-7.22 (m, 1H), 7.18-7.09 (m, 4H), 6.25 (d, 2H), 3.86-3.80 (m, 2H), 3.76-3.70 (m, 6H), 3.53-3.47 (m, 2H), 2.91-2.87 (m, 4H), 1.85-1.77 (m, 2H), 1.52-1.42 (m, 2H), 1.36 (t, 3H), 1.22 (t, 3H), 0.99 (t, 3H); Mass Spectrum: M+H+ 530.

Sources & evidence

ORD record
ord-686fa6233d264b71a0812054d4c49cd6
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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