HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate → tert-Butyl octahydro-5H-pyrrolo(3,4-c)pyridine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate | HCID 21041208 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl octahydro-5H-pyrrolo(3,4-c)pyridine-5-carboxylate | HCID 19691292 | 99.8% |
Reaction Steps
2-Benzyloctahydropyrrolo[3,4-c]pyridine-5-carboxylic acid tert-butyl ester (Example A26, 24.98 g, 78.8 mmol) in 400 mL of methanol is treated with 2.5 g of 20% Pd/C and shaken for 20.5 hours under 50 PSI of hydrogen. The solution is filtered and concentrated to afford 17.8 g of the title compound as a solid. MS APCI: m/z 228 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582627B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f44e53249df54f26ab25a19c9ac68829 |
| Source note | uspto-grants-2009_09 |