反应详情

温度

55 °C

A methanol (30 mL) suspension of methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate from Step 3 (2.00 g, 4.87 mmol) in a sealed tube was saturated with ammonia gas at 0° C. The mixture was then heated in an oil bath at 55° C. for two days. The reaction mixture was cooled and evaporated. To the white solid residue was added ether followed by filtration to provide the title compound.

1. temperatureThe reaction mixture was cooled
2. customevaporated
3. additionTo the white solid residue was added ether
4. filtrationfollowed by filtration