Sodium Hydroxide → (5-{2-[4-(5-Bromo-2-chlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid

Participants

Reaction Steps

To a solution of the ethyl (5-{2-[4-(5-bromo-2-chlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetate (50 mg, 0.096 mmol) in THF (319 μL) and MeOH (159 μL) was added 2 N NaOH (96 μL, 0.191 mmol) and the was mixture stirred at RT for 10 min. The THF and MeOH were evaporated and the aqueous layer was washed with Et2O (2×2 mL). The aqueous layer was acidified to pH 1 with 2 N HCl and stirred for 5 min. The mixture was filtered and washed with water followed by 1:1 Et2O/hexanes. The solid was dried under high vacuum to afford the title compound.

Provenance & Evidence