HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → (5-{2-[4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2-Chloro-5-fluorophenol | HCID 2724522 | — |
| Reactant | Ethyl {5-[2-(4-hydroxypiperidin-1-yl)pyrimidin-5-yl]-2H-tetrazol-2-yl}acetate | HCID 86621801 | — |
| Product | (5-{2-[4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid | HCID 57832735 | — |
Reaction Steps
The title compound was prepared in a similar manner as that described for Example 3 (step 4) from ethyl {5-[2-(4-hydroxypiperidin-1-yl)pyrimidin-5-yl]-2H-tetrazol-2-yl}acetate, 2-chloro-5-fluorophenol, triphenylphosphine and diethyl azodicarboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582633B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-40751fe3e71a46f38735365d9320cc99 |
| Source note | uspto-grants-2009_09 |