HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → (5-{2-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 2-Bromo-5-fluorophenol | HCID 2724600 | — |
| Reactant | Ethyl {5-[2-(4-hydroxypiperidin-1-yl)pyrimidin-5-yl]-2H-tetrazol-2-yl}acetate | HCID 86621801 | — |
| Product | (5-{2-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid | HCID 24970225 | — |
Reaction Steps
The title compound was prepared in a similar manner as that described for Example 3 (step 4) from ethyl {5-[2-(4-hydroxypiperidin-1-yl)pyrimidin-5-yl]-2H-tetrazol-2-yl}acetate, 2-bromo-5-fluorophenol, triphenylphosphine and di-tert-butyl azodicarboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582633B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-82e99a0a93cf4f71860eb3ae41e5a955 |
| Source note | uspto-grants-2009_09 |