Sodium Hydroxide → (5-{2-[4-(2,5-Dichlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid

HRID 729468Notes

Reaction equation

HRID 729468 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:16]=[CH:15][C:14]([C:17]3[N:18]=[N:19][N:20]([CH2:22][C:23]([O:25]CC)=[O:24])[N:21]=3)=[CH:13][N:12]=2)[CH2:7][CH2:6]1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]3[N:18]=[N:19][N:20]([CH2:22][C:23]([OH:25])=[O:24])[N:21]=3)=[CH:15][N:16]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86621804Ethyl (5-{2-[4-(2,5-dichlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetate

Product 1

HCID 57832750(5-{2-[4-(2,5-Dichlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid

Procedure

The title compound was prepared in a similar manner as that described for Example 3 (step 5) from ethyl (5-{2-[4-(2,5-dichlorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetate and aqueous NaOH.

Sources & evidence

ORD record
ord-5d452816740944c282e6121be58fbdd6
Source dataset
uspto-grants-2009_09
Patent number
US07582633B2

Reaction notes

Loading…