Triacetoxyperiodinane → HCID 86621807, compound

Participants

Reaction Steps

Into a 25-mL flask equipped with a magnetic stirbar was added 2-[1-(2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyrimidin-5-yl)-1H-1,2,3-triazol-4-yl]ethanol (50 mg, 0.12 mmol) and dichloromethane (5 mL). To the solution was added Dess-Martin periodinane (59 mg, 0.14 mmol) and the reaction mixture stirred at room temperature for 1 h. The reaction mixture was concentrated and purified by column chromatography through silica gel, eluting with 60:40 Hexanes/EtOAc to 40:60 Hexanes/EtOAc, yielding the desired product as a yellow solid. MS (ESI, Q+) m/z 433 (M+1).

Provenance & Evidence