Sodium hydride → 2-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-5-ethynylpyrimidine

Participants

Reaction Conditions

Reaction Steps

Into a 50-mL round-bottom flask equipped with a magnetic stirbar was added 4-{2-[4-(2-Bromo 5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2-methylbut-3-yn-2-ol (300 mg, 0.69 mmol) and toluene (10 mL). The reaction mixture was treated with sodium hydride (3 mg, 0.07 mmol, 60 wt % in mineral oil) and the contents of the flask heated to 110° C. without attaching a reflux condenser in order to remove the acetone formed during the deprotection stage. After 2.5 h, complete conversion of starting material was observed by TLC analysis. The reaction mixture was cooled to room temperature and then quenched with dropwise addition of a saturated aqueous NH4Cl solution (10 mL). The mixture was poured into a 125-mL separatory funnel containing water (50 mL) and the mixture was extracted with ethyl acetate (3×30 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and the solvent was evaporated under reduced pressure. Purification by column chromatography through silica gel, eluting with 0% EtOAc in hexanes to 20% EtOAc in hexanes as a gradient gave the desired product as a clear oil.

Provenance & Evidence