Triethylamine → HCID 68818057, compound

Participants

Reaction Steps

To 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxamide (0.66 g, 1.8 mmol) in THF (30 mL) at 0° C. was added triethylamine (0.46 g, 4.5 mmol) followed by TFAA (0.57 g, 2.7 mmol). After 15 min at room temperature, the reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate. The organic phase was separated, dried over sodium sulfate and filtered. The residue was purified by flash chromatography to provide the title compound as a white solid.

Provenance & Evidence