Piperazine → HCID 57832796, compound

Participants

Reaction Steps

5-Bromo-2-(4-tert-butyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine (20 mg, 60 μM) and piperazine (21 mg, 244 μM) in DMSO was heated at 80° C. for 8 h. The reaction was cooled and diluted with ethyl acetate (25 mL) and water (25 mL). After partitioning the ethyl acetate layer was washed with water (3×) and dried over magnesium sulfate. After filtering and concentration the title compound was obtained in 80% yield. LC/MS (Method A): r.t.=1.26 min. calculated mass=335 [M+H]+=336.

Provenance & Evidence