Acetone → HCID 68905789, compound

Participants

Reaction Steps

The mixture of 25 mg (0.066 mmol) {4-[5-(2,5-diaza-bicyclo[2.2.1]hept-2-yl-)-imidazo[1,2-c]pyrimidin-7-yl]-pyridin-2-yl}-(1,2-dimethyl-propyl)-amine in 5 mL chloroform was treated with 38 mg (0.66 mmol) acetone, 41 mg (0.66 mmol) NaBH3(CN) and 1 mL methanol. The mixture was stirred at rt for 15 h. MS showed all starting materials were converted. The mixture was diluted with 100 mL DCM, washed with 20 mL sat. NaHCO3, dried over anhydrous Na2SO4. After purification by chromatography, obtained the title compound as a yellow solid. MS (ES+): 420 (M+H)+.

Provenance & Evidence