Butanal → HCID 68911840, compound

Participants

Reaction Steps

A solution of 25 mg (0.061 mmol) {4-[5-(2,5-diaza-bicyclo[2.2.1]hept-2-yl)-imidazo[1,2-c]pyrimidin-7-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine in 1 mL chloroform was treated with 0.011 mL (0.12 mmol) butyraldehyde and 26 mg (0.12 mmol) NaBH3(CN) before 1 mL methanol was consequently added. The mixture was stirred at ambient temperature for 15 h when MS showed that all starting materials had converted to product. The reaction mixture was diluted with 20 mL DCM, washed with 20 mL satd. NaHCO3, and dried over anhydrous Na2SO4. After purification by chromatography, the title compound was obtained. MS (ES+): 468 (M+H)+.

Provenance & Evidence